Irina Kufareva
Irina received a M.S. in Mathematics and Computer Science in 1994, and Ph.D. in Computer Science in 2000, both from Tomsk State University, Russia, the latter under the mentorship of Prof. Nina Yevtushenko. Having relocated to the US, Irina eventually arrived at computational biology as the discipline of great importance, great challenges, and great opportunities for scientific discovery using computer science approaches. As a postdoc under the guidance of Prof. Ruben Abagyan at the Scripps Research Institute, La Jolla, she mastered molecular modeling and docking, as well as computational chemistry, bioinformatics, and cheminformatics. Following her transition to UCSD in 2009, she educated herself in experimental biology and pharmacology, which altogether gave her a unique research perspective at the interface of computational and experimental science. The long-standing goal of her work is to elucidate the structural, molecular, and architectural principles of cell signaling. In her leisure time, she enjoys hiking, music, and educated stargazing.
Sofia Endzhievskaya, a postdoctoral scholar
Sofia graduated from Moscow Institute of Physics and Technology with a Master's degree in Molecular Biology and Biophysics in 2018. She undertook her PhD in the Randall Centre between 2018 and 2022 between the Parsons and Shaw labs investigating the role of the small GTPase protein RhoE/RND3 signaling in the control of skin homeostasis. Since October 2022, she has been working as a post-doctoral scholar in the School of Pharmacy & Pharmaceutical Sciences at the University of California San Diego on the resolving spatiotemporal signaling model of Gαi protein in CXCR4-expressing cells stimulated with CXCL12 in the Kufareva lab. In her free time, she enjoys any type of outdoor activity.
Kai Wang, a postdoctoral scholar
Kai obtained his Ph.D. from the Chinese University of Hong Kong, by researching the function and structure of a sulfotransferase. He is currently a Postdoc in the Handel and Kufareva labs, embarking on a new journey in GPCR research. His goal is to comprehend the collaborative mechanism of a pair of atypical and canonical chemokine receptors in cancer cell metastasis, employing both experimental and computational approaches. Outside of his academic pursuits, Kai is a passionate enthusiast of plants, especially orchids. He enjoys whatever he enjoys: reading, practicing yoga, exploring psychology, breathing with nature, and striving to become a better man, and TODAY!
Grant Wadman, a staff research associate
Grant graduated from the University of Connecticut with a B.S. in Physiology and Neurobiology. He joined the Kufareva lab in April 2023 after graduating to gain exposure and training in experimental methods and techniques. Grant is working on the experimental aspects of the design and characterization of pharmacological modulators of CCR2. In his free time, he enjoys hiking, camping, reading, and baking.
Alexis Lona, an undergraduate intern
Alexis is a junior at San Diego State University, studying biology with an emphasis in cellular and molecular biology and minoring in honors interdisciplinary studies. He joined the Kufareva lab for a short summer internship in 2019 and returned in the Fall 2020. He is developing computational methods for analyzing quantitative mass spectrometry data from the spatiotemporally resolved APEX experiments on G proteins and G protein coupled receptors (GPCRs) and integrating this data into cohesive models of target trafficking and interactome. During his free time, Alexis enjoys running outside, donating platelets, and making coffee.
Andrew Tsui, a high-school intern
Andrew is a rising senior at Canyon Crest Academy in Carmel Valley. Joining the Kufareva Lab as an intern in 2022, he is seeking to develop experimental skills for a potential future career in the field of biological research, which includes learning molecular biology cloning, cell culture, various biochemical assays, and contributing to the ongoing projects in the lab. During his free time, Andrew enjoys reading about art history, golfing, playing tennis, and hanging out with friends.
Jingyi "Shirley" Xie, an undergraduate intern
Jingyi is a Junior at University of California, San Diego, studying biology with specialization in bioinformatics and minoring in psychology, planing to go to medical school. She joined the Kufareva Lab in October 2022. She is devoted to construct connexin40 structural model and find possible specific opener for this protein. During her free time, she enjoys being a stage actor, hanging out with her dog Chuchu, and exploring different food.
Gavin Tan, an undergraduate intern
Gavin is a Senior at UC San Diego, studying biochemistry and computer science. As a Kufalab intern, he designs and implements computational tools for GPCR computational structural biology. He has so far created a framework for high-throughput AlphaFolding of receptor-ligand complexes and helped demystify the structure-function relationship in an inflammation-fueling chemokine receptor. In his free time, he enjoys baking, badminton, and learning about mycology.
Luya Wei, an undergraduate intern
Luya is an undergraduate at UC San Diego studying biotechnology and mathematics for applied science. He joined the Kufareva Lab in 2024 as an undergraduate intern, and is currently working on developing assays for measuring gap junction channel permeability in live cells. During his free time, Luya enjoys running, gymnastics, and listening to music.
Laurence Xu, an undergraduate intern
(pending)
John Randolph Dillon Dawson, a postdoctoral scholar
John specializes in protein modeling, virtual ligand screening, and molecular dynamics. In the Kufareva Lab at the University of California San Diego, he is developing new drug screening pipelines for chemokine receptor complexes with the intent to identify potential therapeutics. He received his PhD in Biophysics (2022) from the University of California Davis under the supervision of Prof. Igor Vorobyov, where he employed computational modeling to better understand cardiotoxic drug interactions. His dissertation elucidated ion conduction and stereospecific drug blockade of the notorious hERG potassium channel and further modeled drug interactions with beta adrenergic receptors. He has a BA in Biochemistry (2014) from Occidental College. His hobbies include horticulture, various forms of fermentation, and reef aquaria.
Rezvan "Leila" Chitsazi, a postdoctoral scholar (2021-2022)
Leila received her PhD in Computational Physical-Chemistry from University of Columbia-Missouri under supervision of Prof. Tommy Sewell in Dec 2018. She then joined National Institutes of Health/National Institute on Drug abuse as a Visiting Postdoctoral Fellow to focus on structural and mechanistic studies of G-protein-coupled receptors (GPCRs), mainly cannabinoid receptor 1 (CB1). As part of the Kufareva team, she continued working on GPCRs (this time chemokine receptors). In her free time she loves to grow plants, cook (Persian style) and work out.
Kirti Kandhwal Chahal, a postdoctoral scholar (2017-2021)
Kirti obtained her Masters degree in Pharmacology in 2006 from Guru Jambheshwar University of Science and Technology (GJUS&T), India. Then she joined Ranbaxy Research Laboratories, India and worked there as a research scientist in the department of Clinical Pharmacology and Pharmacokinetics until 2014. In 2013, while still in Ranbaxy, she started her Ph.D. to investigate repositioning of medicines for new therapeutic indication as Hedgehog pathway inhibitors using in-silico screening and in-vitro studies. She got trained in in-silico studies and in-vitro experiments while working as a volunteer in Abagyan Lab at the UCSD Skaggs School of Pharmacy, La Jolla, CA, under the guidance of Drs. Ruben Abagyan and Irina Kufareva. Since Dec 2017, she has been a member of the Kufareva group, working on projects related to chemokine receptor and Hedgehog pathway; in 2021, she successfully defended her PhD thesis and became a postdoc. In 2021, Kirti moved on to a research [psition in industry. In her spare time, she likes to paint and make useful crafty things. Recently she started a small garden in our balcony which she wants to expand to full kitchen garden.
Ekta Khare, a staff research associate (2019-2022)
Ekta obtained her Masters degree in Microbiology in 2003 from Bundelkhand University, India. She moved to San Diego, California in 2015. In 2021, she completed ‘Certificate of Achievement in Biotechnology’ from Miramar Community College, San Diego. She joined the Kufareva Lab in November 2019 as a volunteer Lab Assistant and has been helping the lab with their various projects. In 2022, she became a Staff Research Associate. She acquired an extensive hands-on experience in molecular biology, mammalian cell culture, and pharmacological assays. She then moved on to start her career in industry. In her free time, Ekta enjoys listening to music, painting, and outdoor activities. She is also keen in investing her time with her family and friends.
Julie Resnick, an undergraduate intern (2021-2022)
Julie graduated UCSD with a major in Cognitive Behavioral Science and is pursuing a pre-med route. Through her work in the Kufareva group during her senior year, she obtained wet-lab experience including work with mammalian cells and pharmacological assays to assess their signaling. She was excited to learn about GPCRs and observe the role of different effectors in their downstream signal transduction. In her free time, Julie enjoys being outside, listening to music, and going on walks.
Sohini Mody, a high-school intern (2022-2023)
Sohini graduated from Mater Dei Catholic High School in Chula Vista in 2023. As a Kufareva lab intern, she has got lots of hands-on experience working in a laboratory setting and studying basic bench techniques, cell culture, and biochemistry assays; she also made great contributions to the ongoing research projects. Upon high school graduation, Sohini was accepted to a prestigious BS/MD program. In her spare time, Sohini enjoys going on walks and spending time with her dog.
Beatrice Acot, a high-school intern (2021)
Beatrice graduated Eastlake High School in Chula Vista in 2022 and was accepted to UC San Diego. As a Kufareva lab intern during her high school senior year, she developed her understanding of cancer receptor pathways and obtained hands-on experience working in a laboratory setting. In her free time, Beatrice enjoys trying new restaurants, being out with friends, playing the cello or violin, and listening to music. Additionally, she loves Red Velvet (the cake and the K-Pop group).
Dmytro "Dima" Ilnytskyy, an undergraduate intern (2021)
Dmytro has graduated from Poway High School in June 2021 and is now an undergraduate at UC San Diego. In Feb 2021, while still in high school, he joined the Kufareva lab and is studying basic bench techniques, cell culture, and pharmacological assays, contributing to the many projects in the lab. In his free time, Dima enjoys reading and developing his startup that offers tech help to local seniors.
Tony Ngo, a postdoctoral fellow (2017-2020)
Tony was born and raised in Sydney, Australia where he received his PhD in Pharmacology from the Victor Chang Cardiac Research Institute and the University of New South Wales. In his research career so far, he has been at the interface of computational biology, pharmacology and now structural biology, using both in silico and in vitro techniques to understand the structure-function of GPCRs, particularly orphan and protein-binding receptors and has broad interests in protein-protein interactions. While in the Kufareva lab, he has been supported by an NHMRC CJ Martin Fellow and was working on designing and developing various protein scaffolds as pharmacological tools to study chemokine receptor interactions. He enjoys exploring new places, hiking and live music.
See also: https://twitter.com/tngo715
Suchismita Roy, a postdoctoral researcher (2017-2021)
Suchi graduated from University of Delhi, Dept. of Botany in 2011 and obtained her Ph.D. from Jawaharlal Nehru University, New Delhi in Life Sciences in December 2016. She joined Kufareva group as a volunteer in March 2018, and as a postdoc in July 2018. Her research interests solely lie in protein biology, structure, evolution, function and mechanism. Her research project in the Kufareva lab was focused on structural and biophysical studies on heteromeric G protein with their non-canonical modulators. She is passionate about photography. Other than that - experimenting with food and painting at leisure.
Åge Aleksander Skjevik, a visiting postdoctoral fellow (2018)
Åge graduated as Master of Pharmacy from the University of Bergen (UiB), Norway in 2008 and received his PhD at the Department of Biomedicine, UiB in 2013. He spent the next four years as a postdoctoral fellow at San Diego Supercomputer Center, UCSD and has now returned to UiB for his second postdoc period. He is currently a visiting scholar in the Kufareva lab. His research field of interest is pharmaceutically relevant computational biology, with a main focus on molecular dynamics simulation methodology. In his spare time, Skjevik enjoys spending time with friends, watching soccer or a good Netflix series, live music, IPA tastings and travel.
Willow Carretero, staff research associate (2018-2021)
Willow is a third-year undergraduate at MIT majoring in Biology. Her projects during her time at the Kufareva lab (2018-2021) included protein binding pocket structure analysis, phosphoproteomic data analysis, and development of a toolkit for the development of mechanistic cell signaling models. Willow hopes to continue to do research at the intersection between computation and cell, structural, and protein biology. Her hobbies include making and listening to electronic music, traveling, and hiking.
Weijun Xu, a postdoctoral researcher (2018-2019)
Weijun completed undergraduate studies (B.Sc. Hons. Biochemistry) from the University of Queensland in 2006 (full pay study leave sponsored by Singapore Polytechnic). He then undertook a lecturer position at the School of Chemical and Life Sciences (Singapore Polytechnic) from 2007-13. He received PhD from Institute for Molecular Bioscience, UQ in 2017 and continued his postdoc study at the IMB under the supervision of Prof. David Fairlie. His research interests include computational biology/chemistry, molecular pharmacology and structural biology. As a postdoc in the Kufareva lab, he lifted off the ground the project focused on computational modeling of cell signaling downstream of CCR2. Weijun loves singing, swimming, cooking and travelling.
Alara Tuncer, an undergraduate intern (2019)
Alara graduate from UCSD with a major in Biochemistry/Chemistry and minor in Biology and Political Science. During her junior year, as an undergraduate intern in the Kufareva lab, she was assisting lab members with their experiments. She is interested in Virology and Immunology and hopes to do research within these fields in the future. In her free time, Alara enjoys playing the piano, spending time outdoors and reading
Margaret Misyutina, a summer undergraduate intern (2019)
Margaret graduated UC Berkeley in the College of Letters and Sciences with a double major in Data Science and Computer Science. Her summer project with the Kufareva lab involved writing Python and R computer code for effective visualization and presentation of reaction-contingency networks of GPCR signaling. In her free time, Margaret loves traveling, hiking, gymnastics, and volunteering with disadvantaged youth.
Positions
There are no open salaried positions at this time. However, we always welcome unpaid interns and applicants with their own scholarship funding.
Please send your CV, cover letter, and three professional references (contact info only), including the current or previous academic supervisor, to ikufareva@health.ucsd.edu.